New York Eye and Ear Infirmary
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Research Report

The following list includes externally funded research activities in the past 5 years, as of March 1, 2000.

Facial Plastic & Reconstructive Surgery

    A. Periosteal Fixation in Endoscopic Forehead Lifting
    B. Project P.I.: Thomas Romo, III, MD
    C. Funding Source: W.L. Lorenz, Inc.
    D. Funding Amount: $5000
    E. Term of Support: 1/19/98- 6/19/98
    F. Presentations and Presentations:

Presentation at the American Academy of Facial Plastic & Reconstructive Surgery, San Antonio, TX, September 9, 1998

Romo T, Sclafani AP, Yung R, McCormick SA, Cocker R, McCormick S. Endoscopic foreheadplasty: a histologic comparison of periosteal refixation after endoscopic versus bicoronal lift. Plast Reconstr Surg, in press.

Romo T, Sclafani AP, Yung R. Endoscopic foreheadplasty: clinical results of temporary versus permanent fixation. Aesth Plast Surg 1999; 23: 388-394.

A. Evaluation of micronized alloderm in soft tissue repair
B. Project P.I. Anthony P. Sclafani, MD
C. Funding source: LifeCell Corporation
D. Funding amount: $115,010
E. Term of support: 2/1/99 - 8/1/00
F. Presentations and Publications:

American Academy of Facial Plastic & Reconstructive Surgery, Annual Meeting. "Micronized Alloderm for soft tissue augmentation: clinical results and histologic findings." New Orleans, LA, September 22, 1999.

A. Persistence of volume enhancement following Alloderm grafting
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: LifeCell Corporation
D. Funding Amount: $32,875
E. Term of Support: April 1998- April 1999
F. Presentations and Publications:


American Academy of Facial Plastic & Reconstructive Surgery, Spring Meeting. "Acellular dermal graft (Alloderm) as a filler for soft tissue defects: clinical observations and histologic findings", Palm Desert, CA, April 28, 1999.

A. Long term evaluation of homologous collagen dispersion (Dermologen) for soft tissue augmentatio
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: Collagenesis Corporation
D. Funding Amount: $27,450
E. Term of Support: November 1998- November 1999

A. Long term evaluation of autologous collagen dispersion (Autologen) for soft tissue augmentation
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: Collagenesis Corporation
D. Funding Amount: $112,625
E. Term of Support: September 1997- ongoing
F. Publications and Presentations:

Sclafani AP, Romo T, Parker A, McCormick SA, Cocker R, Jacono A. Evaluation of autologous collagen dispersion for soft tissue augmentation. Arch Facial Plast Surg (in-press)

American Academy of Facial Plastic & Reconstructive Surgery, Spring Meeting. "Autologous collagen dispersion (Autologen) as a dermal filler: clinical observations and histologic findings", Palm Desert, CA, April 28, 1999.

A. Alloderm grafting of the peritonsillar fossa after tonsillectomy for post-operative pain control
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: LifeCell Corporation
D. Funding Amount: $10,000
E. Term of Support: March 1998- August 1998

A. Effect of Fibroblast Growth Factor on Tissue Ingrowth into Porous High D ensity Polyethylene Implants
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: Porex Surgical, Inc.
D. Funding Amount: $3755
E. Term of Support: April 1998- July 1998
F. Publications and Presentations:

Sabini P, Sclafani AP. Modulation of fibrovascular ingrowth into porous high density polyethylene (PHDPE) implants with basic fibroblast growth factor (b-FGF) and autologous blood clot (ABC). Arch Facial Plast Surg (in-press).

American Academy of Facial Plastic & Reconstructive Surgery, Palm Desert, CA, May 1999: "The effect of topical blood clot and growth factors on soft tissue ingrowth into PHDPE implants".

A. Clinical and histologic response of subcutaneous expanded polytetrafluoroethylene (e-PTFE) and porous high density polyethylene (PHDPE) implants to experimental infection
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: W. L. Gore & Associates, Porex Surgical, Inc.
D. Funding Amount: $5,600
E. Term of Support: January 1996- May 1996
F. Publications and Presentations:

Sclafani AP, Thomas JR, Cox, A, Cooper M. Clinical and histologic response of subcutaneous expanded polytetrafluoroethylene (e-PTFE) and porous high density polyethylene (PHDPE) implants to acute and early infection. Arch Otolaryngol Head Neck Surg 1997; 123: 328- 36.

American Academy of Facial Plastic & Reconstructive Surgery, Fall Meeting. "Clinical and histologic response of subcutaneous expanded polytetrafluoroethylene (e-PTFE) and porous high density polyethylene (PHDPE) implants to experimental infection", Washington DC, September 28, 1996.

A. Clinical and histologic behavior of exposed porous high density polyethylene implants
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: Porex Surgical, Inc.
D. Funding Amount: $2,500
E. Term of Support: January 1994- March 1994
F. Presentations and Publications:

Seventh International Symposium on Rhinoplasty. "Revision microtia reconstruction using porous high density polyethylene", Orlando, FL, June 20, 1998.

American Academy of Facial Plastic & Reconstructive Surgery, Fall Meeting. "Nasal augmentation using composite allo-implants", San Francisco, CA, September 4, 1997.

American Academy of Facial Plastic & Reconstructive Surgery, Spring Meeting. "Porous high density polyethylene implants in auricular reconstruction", Orlando, FL, May 9, 1996.

American Academy of Facial Plastic & Reconstructive Surgery, Spring Meeting. "Clinical and histologic behavior of exposed porous high density polyethylene implants", Palm Desert, CA, May 3, 1995.

American Academy of Facial Plastic & Reconstructive Surgery, Fall Meeting. "Functional and aesthetic nasal reconstruction using porous high density polyethylene implants", San Diego, CA, September 24, 1994

Sclafani AP, Romo, T. Alloplasts for nasal augmentation. Clinical experience and scientific rationale. Facial Plast Clin North Am, 1999; 7:43-54.

Romo T, Sclafani AP, Sabini P. Reconstruction of the major saddle nose deformity with PHDPE implants. Facial Plast Surg, 1998;14:151-157.

Sclafani AP, Romo T, Silver L. Clinical and histologic behavior of exposed porous high density polyethylene implants. Plast Reconstr Surg, 1997; 99: 41- 50.

Romo T, Sclafani AP, Sabini P. Functional and aesthetic nasal reconstruction using porous high density polyethylene implants. Aesth Plast Surg 1998; 22:211-221.

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Head & Neck Oncology

A. Evaluation of Increased Incidence of Thyroid Carcinoma in Chernobyl Accident Survivors, Pilot Study
B. P.I.: D Branovan, M.D.
C. Funding Amount: $36,000
D. Term of Support: December 1, 1999 – June 1, 2000
E. Funding Source: Donaldson and Freeman Foundation, Knoll Pharmaceuticals

A. Surgical approaches to the anterior and middle skull base
B. Project P. I. Steven D. Schaefer, MD
C. Funding amount: Equipment, supplies
D. Term of Support: 1998 - 2000
E. Funding Source: Dept of Neurosurgery, NYMC and related industry (Zeiss, Mitus Rex)
F. Presentations and Publications:

    Spencer R, Das K, , Nwagwu C, Schaefer S, Wenk E, Weiss M and Couldwell W

    Approaches to the sellar and suprasellar region: Anatomic comparison of microscope versus microscope. Laryngoscope 109:791-794, 1999

    Sabit A, Couldwell W and Schaefer S: Extradural extranasal combined transmaxillary transsphenoid approach to the cavernous sinus: A minimally invasive approach. Laryngoscope 110:286-291, 2000.

    Das K, Spencer R, Nwagwu C, Schaefer S, Wenk E, Weiss M and Couldwell W: Approaches to the sellar and suprasellar region: Anatomic comparison of endonasal-transsphenoidal sublabial-transsphenoidal and transethmoidal approaches. J Neurosurg.

A. Fluorescence Imaging of Tissues
B. Project P.I.: Howard E. Savage, Ph.D.
C. Funding Source: NASA
D. Funding Amount: $20-60,000/yr, increased each year.
E. Term of Support: 9/1/94 - 9/1/99
F. Publications and Presentations:

    Schantz, S. P., Savage, H. E., Sacks, P. G., Silverberg, M., Lipkin, M., Yang K., Tang, G. C., Alfano, R. R. Tissue autofluorescence spectroscopy: an intermediate endpoint for chemopreventive agents. Proceedings of International Society for Optical Engineering 25:195-205, 1993.

    Silberberg, M. B., Savage, H. E., Tang, G. C., Sacks, P. G., Alfano, R.R. and Schantz, S. P. Detecting retinoic acid induced biochemical alterations in squamous cell carcinoma using intrinsic fluorescence spectroscopy. Laryngoscope 104:278-283, 1994.

    Savage, H. E., Kolli, V., Zhang, J., Alfano, R. R., Sacks, P. G. and Schantz, S. P. Tissue autofluorescence spectroscopy: in vivo alterations may reflect cellular proliferation. SPIE Proc 2135: 16-25, 1994.

    Franceschi, D., Haldar, J., Alfano, R.R., Savage, H.E., Schantz, S.P. In-vivo fast fourier transform analysis of the autofluorescence of normal and neoplastic upper aerodigestive mucosa. Surgical Oncology, 8:488-492, 1994.

    Glasgold, R., Glasgold, M., Savage, H., Pinto, J., Alfano, R., Schantz, S. P. Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis. Cancer Letters 85:223-232,1994.

    Savage, H. E., Kolli, V., Ansley, J., Chandawarkar, R. Y., Alfano, R. R. and Schantz, S.P. Innate tissue fluorescence of the oral mucosa of controls and head and neck cancer patients. SPIE Proc 2387: 2-14, 1995.

    Savage, H. E., Kolli, V., Saha, S., Zhang, J-C., Glasgold, M., Sacks, P.G., Alfano, R. R. and Schantz, S. P. Development of in vitro models to elucidate mechanisms of intrinsic cellula r and tissue fluorescence. SPIE Proc 2387: 44-56, 1995.

    Kolli, V. R., Shaha, A. R., Savage, H. E., Sacks, P. S., Casale, M. A. and Schantz. Native cellular fluorescence can identify changes in epithelial thickness in vivo in the upper aerodigestive tract. Amer. J. Surg. 170:495-498, 1995.

    Kolli, V. R., Savage, H. E., Yao, T. J. and Schantz, S. P. Native cellular fluorescence of neoplastic upper areodigestive mucosa. Arch. Otolaryngol Head Neck Surg. 121:1287-1292, 1995.

    Cordeiro, P. G., Kirschner, R. E., Hu, Q-Y., Chial, J. J. C., Savage, H., Alfano, R. R., Hoffman, L. A., and Hidalgo, H. Ultraviolet excitation fluorescence spectroscopy: A noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps. Plastic and Reconstructive Surg. 96:673-680, 1995.

    Sacks, P. G., Savage, H. E, Levine. J., Kolli, V. R., Alfano, R. R. and Schantz, S. P. Native cellular fluorescence identifies terminal squamous differentiation of normal oral epithelial cells in culture: a potential chemoprevention biomarker. Cancer Letters 104:171-181, 1996.

    Katz, A., Ganeson, S., Savage, H. E, Schantz, S. P. and Alfano, R. R. Optical biopsy fiber based on fluorescence instrumentation. SPIE 2679:118-123, 1996.

    Davis, R. A., Savage, H. E., Alfano, R. R. and Schantz, S. P. Influence of keratin on native cellular fluorescence of human skin. SPIE 2679:216-226, 1996.

    Zhang, J. C., Savage, H. E., Sacks, P. G., Delohery, T., Alfano, R. R., Katz, A. and Schantz, S. P. Innate cellular fluorescence reflects alterations in cellular proliferation. Lasers in Surg. Med. 20:319-331, 1997.

    Schantz, S. P., Savage, H. E., Sacks, P. G. and Alfano, R. R. Native cellular fluorescence and its application to cancer prevention. Environ. Health Perspect.(Sup 105 pl. 4):941-944, 1997.

    Katz, A., Savage, H. E., Zeng, F., Rome, J., Tang, C. C., Harris, D., Koutcher, J., Schantz, S. P., and Alfano, R. R. Ratio mapping system for tissue diagnosis. SPIE,3250:64-67, 1998.

    Yang, Y., Liu, C. H., Savage, H. E., Schantz, S. P. and Alfano, R. R. Optical fluorescence and Raman biopsy of squamous cell carcinoma from the head and neck. SPIE,3250:68-71, 1998.

    Schantz, S. P., Kolli, V., Savage, H. E., Yu, G., Shah, J. P., Harris, D. E., Katz, A., Alfano, R.R. and Huvos, A. G. In vivo native cellular fluorescence and histological characteristics of head and neck cancer. Clin. Cancer Res. 4:1177-1182, 1998.

    Silverberg, M., Savage, H. E., Tang, G. C., Sacks, P. G., Alfano R. R., and Schantz, S. P. Differences in spectral patterns between retinoic acid treated and untreated squamous cell carcinoma spheroids. Presented at the Triologic Soc., Amer. Acad. of Laryn., Otol. and Rhinol., 1993.

    Schantz, S. P., Savage, H. E. and Alfano, R. R. Intrinsic autofluorescent properties of aerodigestive mucosa, Presented at Amer. Soc. Head and Neck Surg., 1993.

    Schantz, S. P., Savage, H. E., Sacks, P. G., Silverberg, M., Lipkin, M., Yang, K., Tang, G. C. and Alfano, R. R. Tissue autofluorescence spectroscopy: An intermediate endpoint for chemopreventive agents. Presented at the Proceedings of the International Society for Optical Engineering, 1993.

    Glasgold, M., Savage, H.E., Pinto, J.T., Alfano, R.R., Schantz, S.P. Tissue autofluorescence spectroscopy for the detection of premalignancy in NMBA-induced esophageal carcinogenesis. Presented at Triologic Eastern Section Meeting, 1994.

    Franceshi, D. Haidar, J. Alfano, R.R., Savage, H.E., Schantz, S.P. In-vivo fast fourier transform analysis of the autofluorescence of normal and neoplastic upper aerodigestive mucosa. Presented at Chicago School of Surgeons, 1994.

    Zhang, J. C., Sacks, P. G., Savage, H. E., Schantz, S. P. Tissue autofluorescence identification of in vitro cellular proliferation. Recieved AACR travel award, rated as meritorius abstract by board of directors of AACR. Proceedings American Association for Cancer Research. 35:620, 1994.

    Savage, H. E., Sacks, P. G., Kolli, V., Harris, D. and Schantz, S. P. Intrinsic tissue fluorescence can identify retinoic acid induced changes in a multicellular tumor spheroid (MTS) model. Head and Neck 16:495, 1994.

    Saha, S., Hughes, C. J., Cabal, R., Pinto, J. T., Savage, H. E., Reed, J. A., Schantz, S. P. and Albino, A. P. Enhanced utility of an in vivo field cancerization model through in situ hybridization analysis. Presented: Fourth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, Arlington, Va., 1994.

    Saha , S., Savage, H.E., Pinto, J. T., Quiao, C. H.. Sacks, P. G. and Schantz, S. P. Autofluorescence changes in progressive esophageal neoplasia in the Sprague-Dawley rat as a model for field cancerization of the upper aerodigestive mucosa. Head and Neck 16:510, 1994.

    Ansley, J. F., Savage, H. E. and Schantz, S. P. Auto-fluorescence profiles of normal oral cavity mucosa. Head and Neck 16:487, 1994.

    LoPresti, P. J., Savage, H.E., Sacks, P. G., and Schantz, S. P. Cytokeratins: Detection of these markers of tissue differentiation using autofluorescence scanning. Head and Neck 16:489, 1994.

    Kolli, V. K., Savage, H. E. and Schantz, S. P. In vivo tissue autofluorescence of neoplastic aerodigestive tract mucosa. Head and Neck 16:488, 1994.

    Chandawarkar, R. Y., Savage, H. E., Ansley, J., Kolli, V., Alfano, R. R. and Schantz, S. P. Tobacco-induced alterations of native cellular fluorescence of the oral cavity. Presented: Fourth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, Arlington, Va., 1994.

    Parisier S. C., Goldrich M. S., Savage H., Schantz S. P. Intrinsic cellular and tissue fluorescence as a methodology for differentiating cholesteatoma from auricular epithelia. Otolaryngology Head and Neck Surgery 111:126, 1994.

    Savage, H. E., Kolli, V., Saha, S., Zhang, J-C., Glasgold, M., Sacks, P., Alfano, R. R. and Schantz, S. P. Development of in vitro models to elucidate mechanisms of intrinsic cellular and tissue fluorescence. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1995 SPIE Proc, Biomedical Optics '95.

    Savage, H. E., Kolli, V., Ansley, J., Chandawarkar, R. Y., Alfano, R. R. and Schantz, S.P. Innate tissue fluorescence of the oral mucosa of controls and head and neck cancer patients. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1995 SPIE Proc, Biomedical Optics '95.

    Alfano, R. A., Liu, C. H., Glassman, W. L., Tang, G., Savage, H. E., Schantz, S. P., Lubicz, S. and Celmer, E. Raman spectroscopy as a molecular diagnostic tool for tissues. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1995.

    Kolli, V. R., Savage, H. E. and Schantz, S. P. In vivo native cellular fluorescence can identify changes in the oral mucosal thickness., AACR 1995.

    Sacks, P. G., Savage, H. E., Levine, J., Kolli, V. and Schantz, S. P. Tissue autofluorescent identification of in vitro epithelial differentiation: a potential chemopreventive biomarker. AACR, 1995.

    Kolli, V. R., Shaha, A. R., Savage, H. E., Sacks, P.G., Casale, M. A. and Schantz, S. P. Native cellula fluorescence can identify changes in epithelial thickness in vitro in the upper digestive tract. Head and Neck Surgeons Meeting, Boston, 1995.

    Savage, H. E., Parisier, S. C., Goldrich, M. S, Han, J. C., Alfano, R. R. and Schantz S. P. Differentiation of cholesteatoma and other ear epithelia using intrinsic cellular and tissue fluorescence. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1996.

    Sacks, P. G., Savage, H. E., Levine, J., Kolli, V., Alfano, R. R. and Schantz, S. P. Tissue autofluorescent identification of in vitro epithelial differentiation: a potential chemopreventive biomarker. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1996.

    Katz, A., Ganeson, S., Savage, H. E., Schantz, S. P. and Alfano, R. R. Optical biopsy fiber based on fluorescence instrumentation. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1996.

    Davis, R. A., Savage, H. E., Alfano, R. R. and Schantz, S. P. Influence of keratin on native cellular fluorescence of human skin. Proceedings of International Society for Optical Engineering, San Jose, Cal. February, 1996.

    Katz, A., Ganesan, S., Alfano, R. R., Savage, H. E. and Schantz, S. P. Development of real time optical biopsy instrumentation for cancer diagnosis using fluorescence spectroscopy. Abst. 565,Pitcon' 96, March 3-8, Chicago, Ill., 1996

    Savage, H. E., Katz, A., Harris, D., Ganesan, S., Alfano, R. R. and Schantz, S. P. S. The hamster skin and DMBA-treated cheek pouch as in vivo models to study native cellular and tissue fluorescence. Presented at the Fourth International conference on head and neck cancer. Toronto, Canada, July 28-August 1, 1996.

    Schantz, S. P., Harris, D., Savage, H. E., Yu, G. P., and Alfano, R. R. Native cellular fluorescence (NCF) and field cancerization. Presented at the Fourth International conference on head and neck cancer. Toronto, Canada, July 28-August 1, 1996.

    Schantz, S. P., Savage, H. E., and Harris, D. Native cellular fluorescence detects biologic characteristics of head and neck cancer. American Society for Head and Neck Surgery, Scottsdale, Arizona, May, 11-13, 1997.

    Katz, A., Savage, H. E., Zeng, F., Rome, J., Tang, C. C., Harris, D., Koutcher, J., Schantz, S. P., and Alfano, R. R. Ratio mapping system for tissue diagnosis. SPIE, 1998, San Jose, Cal. Jan, 1998.

    Yang, Y., Liu, C. H., Savage, H. E., Schantz, S. P. and Alfano, R. R. Optical fluorescence and Raman biopsy of squamous cell carcinoma from the head and neck. SPIE, 1998, San Jose, Cal. Jan, 1998.

    Katz, A., Savage, H. E.,Basuk, P., Altorki, N., Godwin, T., Alfano, R. R. Dection of Barrett's esophagus by ultraviolet and visible Fluorescence, emission and excitation spectroscopy. OSA Annual Meeting, Baltimore Convention Center, Baltimore, Md., Oct. 7, 1998.

A. Nonlinear Optical Histological and Tomographic Imaging and Spectral Interference Tomographic Imaging as Methodologies for the Early Detection of Head and Neck Cancer
B. Project P.I.: Howard E. Savage, Ph.D.
C. Funding Source: Department of Energy (DOE)
D. Funding Amount: $42,000/year
E. Term of Support: January 1, 1998 to 2003
F. Publications and Presentations:

    Guo, Y., Liu, F., Zhadin, N., Ho, P. P., Savage, H., Harris, D., Sacks, P., Schantz, S. and Alfano, R. R. Second harmonic and two-photon fluorescence nonlinear optical histology of tissues. SPIE, 3250:210-212, 1998.

    Liu, F., Guo, Y., Alfano, R. R., Savage, H. E., and Schantz, S. P. Subsurface tumor evaluation using noninvasive optical second harmonic imaging. Fifth Research Workshop on the Bioilogy, Prevention, and Treatment of Head and Neck Cancer, McLean, Virgina, Aug 26-30, 1998.

    Guo, Y., Savage, H. E., Liu, F., Schantz, S. P., Ho, P. P., and Alfano, R. R. Optical second-harmonic tomography of subsurface tumor evaluation. OSA Annual Meeting, Baltimore Convention Center, Baltimore, Md., Oct. 7, 1998.

A. Oral leukoplakia and curcumin
B. Project PI: Stimson P. Schantz, MD
C. Funding Source: National Cancer Institute (NCI)
D. Funding Amount: $1,503,545
E. Term of Support: January, 1999 - December, 2002
F. Publications and Presentations:

    Spingaarn, A,, Sacks, P.G., Kelley, D., Dannenberg, A.J., Schantz, S.P.: Synergistic effects of 13-cis retinoic acid and arachidonic acid cascade inhibitors on growth of head and neck squamous cell carcinoma in vitro. Otolaryngol Head Neck Surg 118:159-164, 1998.

    Mestre, J.R., Subbaramaiah, K., Sacks, P.G., Schantz, S.P., Tanabe, T., Inoue, H., Dannenberg, A.J. Retinoids suppress phorbal ester-mediated induction of cycloosygenase-2. Cancer Res 57:1081-1086, 1997.

    Kelley, D..J, Sacks, P.G., Schantz, S.P., Dannenberg, A.J. Curcumin inhibits benzo(a)pyrene and phorbal ester-mediated induction of cyclooxygenase -2 and prostaglandin synthesis in oral epithelial cells. Carcinogenesis 18:795-799, 1997.

    Schantz, S.P., Vaidya, S.G.: Green tea and leukoplakia. American Journal of Surgery 174:552-555, 1997.

    Khafif, A., Schantz, S.P., Chou, T.C., Edelstein, D., Sacks, P.G.: Quantitation of chemopreventive synergism between (-)-epigallochatechin-3-gallate and curcumin in normal, premalignant, and malignant human oral epithelial cells. Carcinogenesis 19:419-424, 1998.

A. Quality of life in patients treated for advanced head and neck cancers: Role of a head and neck support group.
B. Project P.I.: Stimson P. Schantz, MD
C. Funding Source: Langeloth Foundation
D. Funding Amount: $150,000
E. Term of Support: 2000-2001

A.Tobacco Use and Oral Cancer: Etiology and Prevention
B. Project Coordinator: Stimson P. Schantz
C. Funding Source: NIH/NIDCR -01
D. Funding Amount: $3,354,432
E. Term of Support: 1/1/00 - 1/1/03

A. International Centers Against Cancer: Planning Grant.
B. Project collaborator. Stimson P. Schantz, MD
C. Funding source: National Institutes of Health
D. Funding Amount: $250,000
E. Term of Support:: April 1, 2000 – March 31,2003.


A. Cancer susceptibility genes and oral cancer risk.
B. Project collaborator. Stimson P. Schantz, MD
C. Funding source: National Institutes of Health.(NIH CA73173, CA59917, DE12206)
D. Funding Amount: $170,000
E. Term of Support: 4 year grant. 2 1/2 years left.
F. Publications and Presentations:

    Park, J.Y., Muscat, S. P., Schantz, S. P., Stern, J. C., Richie, J. P., and Lazarus, P. GSTM genotype and risk for oral cancer in African Americans and Caucasians. Head and Neck,Abstract, August, 1998.

    Park, J.Y., Muscat, S. P., Schantz, S. P., Stern, J. C., and Lazarus, P. Oral cancer risk associated with polymorphisms in genes coding for GST and CY2E1 enzymes. Head and Neck, Abstract, August 1998.

A. Breast Cancer and Prenatal Exposure to Estrogens
B. Project Collaborator: Guo-Pei Yu, M.D., MPH
C. Funding Source: National Institute of Health (NCI RO1CA54220-01A3)
D. Funding Amount: $508,716
E. Term of Support: 09/30/1993 - 09/29/1996
F. Resultant Presentations and Publications:

    Lipworth L, Hsieh CC, Wide L, Ekbom A, Yu SZ, Yu GP, Xu B, Hellerstein S, Sacks B, Carlstrom K, Trichopolos D, Adami HO. Maternal pregnancy hormone levels in an area with high incidence (Boston, USA) and low incidence (Shanghai, China) of breast cancer. Br J Cancer 1999; 79:7-12.

A. Helicobacter Pylori, Malnutrition, and Gastric Cancer
B. Project Co-PI: Guo-Pei Yu, M.D., MPH
C. Funding Source: National Institute of Health (NIH RO3CA77954-02)
D. Funding Amount: $160,000
E. Term of Support: 09/30/1997 - 09/29/2000
F. Resultant Presentations and Publications:

    Zhang ZF, Kurtz RC, Klimstra DS, Yu GP, Sun M, Harlap S, Marshall JR. Helicobacter pylori infection on the risk of stomach cancer and chronic atrophic gastritis. Cancer Detect Prev 1999;

    23(5):357-367.

    Setiawan VW, Zhang ZF, Yu GP, Li YL, Lu ML, Tsai CJ, Cordova D, Wang MR, Guo CH, Yu SZ, Kurtz RC. GSTT1 and GSTM1 null genotypes and the risk of gastric cancer: a case-control study in Chinese population. Cancer Epidemiology Biomarker and Prevention. 2000; 9(1):73-80

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Hearing & Related Disorders

    A. Eustachian Tube and Middle-Ear Prosthesis Implants: Chronic Ear Disease
    B. Project P.I.: CJ Linstrom, M.D. & CA Silverman, Ph.D.
    C. Funding amount: $377,967
    D. May 1, 1997-March 31, 2000
    E. Funding Source: Rehabilitation Research and Development, Dep’t. Veterans Affairs
    F. Publications and Presentations:

    Linstrom C, CA Silverman, A Rosen, LZ Meiteles. Eustachian Tube Endoscopy in Patients with Chronic Ear Disease Triological Society, Eastern Section Meeting, Pittsburgh, PA, January 30, 2000.

    Linstrom CJ, Silverman CA, Bone Conduction Impairment in Chronic Ear Disease. Annals of Otology, Rhinology and Laryngology (accepted with revisions).

    A. Temporal and Spacial Characteristics of Facial Motion in Normal Persons and Persons with Facial Paralysis.
    B. Project P.I.: CJ Linstrom, M.D., Silverman CA, PhD, Sussman WM, PhD
    C. Funding Amount: $25,000
    D. Term of Support: June 1, 1996 – May 31, 2000
    E. Funding Source: The Ira W. DeCamp Foundation
    F. Publication and Presentation:

    Linstrom CL, CA Silverman, WM Susman: Video-Computer Analysis of Patients with Facial Nerve Disorder. XXII Meeting of the Politzer Society, Zurich, Switzerland August 17, 1999.

    Linstrom CJ, Silverman CA, Susman WM, Persutti T, Colson D, Orquiza C. Video-Computer Analysis of Patients with Facial Nerve Disorders. Triological Society, Eastern Section Meeting, Pittsburgh, PA, January 29- 30, 2000.

    Linstrom CJ, Silverman CA, Susman W. Facial-Motion Analysis with a Video-Computer System: A Preliminary Report. Am. J. Otology 21:123-129, 2000.

    A. Ear Canal Acoustic Reflectance Measurements in the Middle Ear
    B. P.I.: Linstrom CJ M.D. and Silverman CA, PhD
    c. Funding Amount: $36,000
    D. Term of Support: December 16, 1999 – January 1, 2001
    C. Funding Source: National Institutes of Health, 2R44DC03138-02

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Pediatric Otolaryngology

A. Treatment of adenotonsillar hypertrophy with amoxicillin/clavulanate potassium
B. Project P.I.: Anthony P. Sclafani, MD
C. Funding Source: SmithKline Beecham
D. Funding Amount: $17,500
E. Term of Support: September 1993- December 1994
F. Publications and Presentations

    American Academy of Otolaryngology- Head & Neck Surgery, Annual Meeting. "Treatment of adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: 2 year follow-up", San Francisco, CA, September 7, 1997.

    American Academy of Otolaryngology- Head & Neck Surgery, Annual Meeting. "Treatment of adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: a three month follow-up", New Orleans, LA, September 17- 21, 1995.

    Annual Meeting of the American Society of Pediatric Otolaryngologists. "Treatment of adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: short-term results", Durango, CO, May 28, 1995.

    Sclafani AP, Ginsburg J, Shah M, Dolitsky JN. Treatment of symptomatic, chronic adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: short- and long- term results. Pediatrics 1998; 101: 675- 81.

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Voice & Vocal Tract

A. Application of the Wavelet Transform to Investigations of Laryngeal Spasm
B. Project P.I.: Rick M Roark, PhD
C. Funding Source: The Hascoe Foundation
D. Funding Amount: $24,500
E. Term of Support: 10/1/97 to 10/1/00 (renewal in preparation)
F. Publications and Presentations:

    Roark RM, Escabi M (in press) B-Spline design of maximally-flat and prolate spheroidal type FIR filters. IEEE Transactions on Signal Processing

    Escabi M, Roark RM (in review) Using signal reconstruction to obtain precision voice perturbation measures. Journal of the Acoustical Society of America.

    Roark RM (1997) Technological approaches to the observation of peripheral neural function, 26th Annual Symposium of The Voice Foundation, "Care of the Professional Voice," Philadelphia, June.

    Roark RM, Escabi M (1998) Design of digital FIR filters using the cardinal B-spline. International Conference on Signal Processing (ICSP ‘98), Oct 1998, Beijing, China.

A. Thyroplasty Clinical Trials Data Analysis
B. Project P.I. Rick M. Roark, PhD
C. Funding Source: Smith Nephew ENT
D. Funding Amount: $67,200
E. Term of Support: 9/1/98 to 8/31/98 (extended)
F. Presentations and Publications:

Flint P, Cummings C, Roark R(2000) Results of thyroplasty clinical trials. American Laryngological Association Research Conference, January 2000, New York, New York.

    A. Pattern Signatures of Laryngeal Myoelectric Signals
    B. Project P.I. Rick M Roark, PhD
    C. Funding source: National Institutes of Health
    D. Funding amount: $100,000
    E. Term of support: 1/15/99 to 1/14/01
    F. Presentations and Publications
    Li C, Roark R, Schaefer S(2000): Pattern signatures of laryngeal myoelectric signals. American Laryngological Association. May 2000,Orlando, Florida,

    A. Pulmonary Function Measures
    B. Project P. I: Rick M. Roark, PhD
    C. Funding Source: Pak Family
    D. Funding Amount: $20,000

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