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Effectiveness and Safety of Oral Memantine Study

Principal Investigator

Paul A. Sidoti, M.D.

Enrollment Status



To evaluate the effectiveness and safety of Oral Memantine in daily doses of 20mg and 10mg in patients with open-angle glaucoma at risk for glaucomatous progression.

Study Results

Findings from the second Phase 3 clinical trial examining the safety and efficacy of oral Memantine as a treatment for glaucoma. Although the study showed that the progression of disease was significantly lower in patients receiving the higher dose of Memantine compared to patients receiving the low dose of Memantine, there was no significant benefit compared to patients receiving placebo. Therefore, the study failed to meet its primary endpoint and to sufficiently replicate the results of the first Phase 3 trial. While additional analyses are ongoing, the drug company does not believe that these analyses will support an approval of the drug.

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Dr. Paul Sidoti, Principal Investigator

Katy Tai, Research ManagerTel: (212) 979-4251

Address310 E. 14th StreetNew York, NY 10003

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