Comparative Genomic Hybridization

Principal Investigator: Qiang Huang, Ph.D.

Objective: To identify specific alterations in genomic hybridization relevant to disease progression.

Overview: This project utilizes tumor DNA to perform a comparative analysis of cancer to normal tissue. Following polymerase chain reaction amplification of tumor DNA, cancers are assessed for the loss or gain of chromosomal regions. The relationship of these alterations to clinical characteristics of the patient are assessed. Departmental Co-Investigators are Stimson Schantz, MD and John Sonne, MD.

Contact Information: Stimson Schantz, M.D., (212) 979-4200

Selected Publications & Presentations:

Huang Q, Yu GP, McCormick SA, Mo J, Datta B, Mahimkar M, Lazarus P, Schaffer AA, Desper R, Schantz SP. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: Construction of oncogenetic trees for tumor progression. Genes Chromosomes and Cancer 2002; 34:224–233. [Abstract]

Huang Q, Schantz SP, Rao PH, Mo J, McCormick SA, Chaganti RSK. Improving degenerate oligonucleotide primed PCR-comparative genomic hybridization for analysis of DNA copy number changes in tumors. Genes Chromosomes and Cancer 2000; 28:395-403. [Abstract]

Related Information: Other Research Projects in Head and Neck Oncology




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