Use of Curcumin as a Chemopreventive Agent

Principal Investigator: Stimson Schantz, M.D.

Objective: To demonstrate the feasibility and compliance of investigators and study participants in population based clinical trials in high risk regions for oral cancer internationally.

Overview: This project utilizes tumor DNA to perform a comparative analysis of cancer to normal tissue. Following polymerase chain reaction amplification of tumor DNA, cancers are assessed for the loss or gain of chromosomal regions. The relationship of these alterations to clinical characteristics of the patient are assessed. Co-Investigator is Anil d’Cruz, MD.

Contact Information: Stimson Schantz, M.D., (212) 979-4200

Funding: National Institute of Health (National Institute of Dental and Craniofacial Research)     [Read the abstract]

Selected Publications & Presentations:

Khafif A, Schantz SP, Chou TC, Edelstein D, Sacks PG. Quantitation of chemopreventive synergism between (-)-epigallochatechin-3-gallate and curcumin in normal, premalignant, and malignant human oral epithelial cells. Carcinogenesis 1998; 19:419-424. [Abstract]

Spingarn A, Sacks PG, Kelley D, Dannenberg A, Schantz SP. Synergistic effects of 13-cis retinoic acid cascade inhibitors on growth of head and neck squamous cell carcinoma in vitro. Otolaryngology and Head and Neck Surgery 1998; 118:159-164. [Abstract]

Kelley DJ, Sacks PG, Schantz SP, Ramonetti JT, Dannenberg AJ. Curcumin inhibits benzo[a] pyrene and phorbal ester-mediated induction of cyclooxygenase-2 and prostaglandin synthesis in oral epithelial cells. Carcinogenesis 1997; 18:795-799.

Schantz SP, Vaidya SG. Green tea and leukoplakia. American Journal of Surgery 1997; 174:552-555. [Abstract]

Related Information: Other Research Projects in Head and Neck Oncology




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