Tissue Reaction and Persistence of Dermal Allografts

Photo of lipsPrincipal Investigator: Anthony P. Sclafani, M.D., F.A.C.S.

Objective: This project is designed to evaluate 2 allogeneic materials in augmenting soft tissue bulk. The materials are implanted beneath the skin in the area behind the ear. The visible augmentation produced by each implant is then measured by digital photography over a 6 month period. Biopsies of each material are taken over this time and examined for microscopic evidence of rejection, incorporation and resorption.

While the basic goal of the study is to determine which material is better suited for soft tissue augmentation, comparing the implantation of these 2 similar, but distinctly different, materials will improve our understanding of the forces at work in human collagen implants.

Project Co-Investigator is Thomas Romo III, MD, FACS.

Contact Information: Anthony P. Sclafani, M.D., F.A.C.S., (212) 979-4200

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Funding: LifeCell Corporation

Selected Publications & Presentations:

Sclafani AP, Fozo M, Romo T 3rd, McCormick SA. Strength and histology of periosteal fixation to bone after elevation. Arch Facial Plast Surg 2003; 5:63-66. [Abstract]

Sclafani AP, Romo T 3rd, Jacono AA. Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetraâ„¢). Arch Facial Plast Surg 2002; 4:252-257. [Abstract]

Sclafani AP, McCormick SA, Cocker R. Biophysical and microscopic analysis of homologous dermal and fascial materials for facial aesthetic and reconstructive uses. Arch Facial Plast Surg 2002; 4:164-171. [Abstract]

Sclafani AP. The multivectorial subperiosteal midface lift. Facial Plast Surg 2001; 17:29-36. [Abstract]

Sclafani AP, Romo T 3rd. Collagen, human collagen and fat: the search for a three-dimensional soft tissue filler. Facial Plast Surg 2001; 17:79-85. [Abstract]

Sclafani AP, Romo T 3rd, Jacono AA, McCormick SA, Cocker R, Parker A. Evaluation of acellular dermal graft (AlloDerm) for soft tissue augmentation: one year of clinical observations and histologic findings. Arch Facial Plast Surg 2001; 3:101-103. [Abstract]

Related Information: Other Research Projects in Facial Plastics and Reconstructive Surgery

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