Address
New York Eye and Ear Infirmary
310 East 14th Street
New York, NY 10003
Telephone: 212-979-4156 (office)
Fax: 212-677-1284
e-mail:hsavage@nyee.edu
Education
University of Vermont 1960 - 1964, B.S., Burlington, Vermont University
of Vermont 1964 - 1966, M.S., Burlington, Vermont Rutgers the State University
1966 - 1971, Ph.D., New Brunswick, New Jersey
Post-Doctoral Training
Baylor College of Medicine 1971 - 1973, Houston, Texas, Pharmacology
Appointments (current)
The New York Eye and Ear Infirmary Department of Pathology, Cell Biologist,
New York, New York
The Strang Cancer Prevention Clinic , Research Scientist, New York, New York
New York Medical College, Assistant Professor, New York, New York
Appointments (past)
Memorial Hospital, Attending Cell Biologist, New York, New York
Memorial Sloan-Kettering Cancer Center, Assistant Laboratory Member, Department of Head and Neck Surgery, New York, N.Y.
The University of Texas M. D. Anderson Cancer Center, Research Associate, Department of Head and Neck Surgery, Houston, Texas
Baylor College of Medicine, Research Associate, Department of Microbiology and Immunology, Houston, Texas
University of Louisville, Consultant, Department of Physiology, Louisville, Kentucky
Baylor College of Medicine, Consultant, Department of Medicine, Cancer Biology Program, Houston, Texas
Baylor College of Medicine, Senior Research Assistant, Department of Medicine, Houston, Texas
Baylor College of Medicine Instructor, Department of Pharmacology, Division of Oncology, Houston, Texas
Local, State, National, International Committees
Member, Committee on Epidemiology, Prevention and Biologic Markers Dept.
Dept. of Head and Neck Surgery, 6/91-7/98.
Member, Committee on Basic Laboratory Research, Dept. Head and Neck Surgery, 6/91-7/98.
Program committee member, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases I, an International Symposium Sponsored by the Biomedical Optical Society, Los Angles, Ca., 1993-1994.
Program committee member, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, An International Symposium Sponsored by the Biomedical Optical Society, San Hose, Ca., 1994-1995.
Program committee member, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III, An International Symposium Sponsored by the Biomedical Optical Society, San Hose, Ca., 1995-1996.
Program committee member, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III, An International Symposium Sponsored by the Biomedical Optical Society, San Hose, Ca., 1996-1997.
Co-chair, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, Session: Diagnose I, An International Symposium Sponsored by the Biomedical Optical Society, Los Angeles, Cal. Jan. 1994.
Chair, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, Session: Diagnose III, An International Symposium Sponsored by the Biomedical Optical Society, Los Angeles, Cal. Jan. 1994.
Chair, Optical Society of America Annual Meeting, Session: Symposium on Advanced Optical Techniques for Medical Diagnostics: Spectroscopic II., Dallas, Texas, October, 1994.
Co-chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases II, Session 2: Fluorescence spectroscopy to diagnose cancer II. Biomedical Optics '95, San Jose, Ca., Feb. 1995.
Chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases II, Session 3: Raman and imaging spectroscopy. Biomedical Optics '95, San Jose, Ca., Feb. 1995.
Chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases II, Session 4: Spectroscopy studies on tissues and cells. Biomedical Optics '95, San Jose, Ca., Feb. 1995.
Chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases II, Session 6: NIR and scattering and absorption spectroscopy I. Biomedical Optics '95, San Jose, Ca., Feb. 1995.
Chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases III, Session 2: Fluorescence Spectroscopy II. Biomedical Optics '96, San Jose, Ca., Feb. 1996.
Co-chair, Advances in laser and light spectroscopy to diagnose cancer and other diseases III, Session 6: Fluorescence lifetime. Biomedical Optics '96, San Jose, Ca., Feb. 1996.
Co-chair, Advances in laser and light spectroscopy to diagnose cancer
and other diseases III, Session 8: Skin. Biomedical Optics '96, San Jose,
Ca., Feb. 1996.
Editorial Boards
International Journal of Cancer, reviewer Head and Neck, reviewer
Photochemistry and Photobiology, reviewer Cancer, reviewer
Scientific and Medical Socities
American Association for the Advancement of Science MD Anderson Associates Memorial Sloan Kettering Associates New York Academy of Science
Invited Presentations
1. Savage, H. E., Schantz, S. P., and Zhang, J. C. and Alfano, R. R. Relationship
of aerodigestive disease to autofluorescent profiles. Invited presentation,
Presented at SPIE's International Symposium, Los Angeles, 1994.
2. Savage, H. E., Kolli, V., Chandawarkar, R., Zhang, J., Ansley, J., Alfano, R. R and Schantz, S. P. Native tissue fluorescence in normal, preneoplastic and neoplastic tissue of the aerodigestive mucosa. Invited presentation, Optical Society of America Annual Meeting, Dallas, Texas, October, 1994.
3. Savage, H. E., Kolli, V., Ansley, J., Chandarkar, R. Y., Alfano, R.R and Schantz, S. P. Innate tissue fluorescence of the oral mucosa of controls and head and neck cancer patients. Invited presentantion. SPIE's International Symposium, Biomedical Optics '95.
4. Savage, H. E. Invited workshop presentation (Native Cellular Fluorescence of Head and Neck Carcinogenesis) to New York Academy of Science and the Center of Advanced Technology at CCNY, April 24-25, 1997.
Honors and Awards
9/64 - 6/66 University of Vermont Department of Health, Education and
Welfare Training Grant
9/67 - 6/68 University of Vermont Department of Health, Education and Welfare Training Grant
9/69 - 1/71 Rutgers The State University National Science Foundation Grant
9/71 - 6/73 Baylor College of Medicine Department of Health, Education and Welfare Training Grant
Selected Publications
1. Savage, H. E. and Kuchler, R. J. A versatile composite gel column for the electrophoretic separation of ribonucleic acid molecules. Prep. Biochem. 1: 345-360, 1971.
2. Savage, H. E., Grinchishin, V., Fang, W. and Busch, H. Novikoff hepatoma nuclear 8-19S RNA. Chem. and Phys. 6: 113- 126, 1974.
3. Yeoman, L. C., Jordan, J. J., Busch, R. K., Taylor, C. W., Savage, H. E. and Busch, H. A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver. Proc. Natl. Acad. Sci. USA 73: 3258-3262, 1976.
4. Norton, W. N., Daskal, I., Savage, H. E., Seibert, R. A. and Lane, M. Effects of riboflavin deficiency on the ultrastructure of rat sciatic nerve fibers. Amer. J. Pathol. 85: 651-655, 1976.
5. Norton, W. N., Daskal, I., Savage, H. E., Seibert, R. A., Busch, H. and Lane, M. Effects of glactoflavin-induced riboflavin deficiency upon rat hepatoma cell ultrastructure. Virchow S. Arch B. Cell Pathol., 1977.
6. Frenkel, E. P., Kitchens, R. L., Savage, H. E., Seibert, R. A. and Lane, M. Lack of effect of riboflavin deficiency on vitamin B12-related metabolic pathways and aspects of fatty acid synthesis. Amer. J. Clin. Nutr. 32: 59-66, 1979.
7. Marashi, F., Davis, F. M., Busch, R., Savage, H. E. and Busch, H. Purification and partial characterization of nucleolar antigen-1 of the Novikoff hepatoma. Cancer Res. 39: 59-66, 1979.
8. Savage, H. E., Rossen, R. D., Hersh, E. M., Freedman, R. S., Bowen, J. and Plager, C. Antibody development to viral and allogeneic tumor cell associated antigens in patients with malignant melanoma and ovarian carcinoma treated with lysates of virus infected tumor cells. Cancer Res. 46: 2127-2133, 1986.
9. Schantz, S. P., Savage, H. E., Brown, B. W., Reuben, J. M., Hong, W. K., and Rossen, R. D. Association of levels of circulating C1q binding macromolecules with induction chemotherapy responses in head and neck cancer patients. Cancer Res. 48: 5868-5873, 1988.
10. Rossen, R. D., Michael, L. H., Kagiyama, A., Savage, H. E., Hanson, G., Reisberg, M. A., Moake, J.N., Kim, S. H., Weakley, S., Giannini, E. and Entman, M. L. Mechanisms of complement activation after coronary artery occlusion: Evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo. Cir. Res. 62(3):572-584, 1988.
11. Kagiyama, A., Savage, H. E., Michael, L. H., Hanson, G., Entman, M. L. and Rossen, R. D. Molecular basis of complement activation in ischemic myocardium: Identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Cir. Res. 64: 607-615, 1989.
12. Schantz, S. P., Savage, H. E., Racz, T., Liu, F. J., Brown, B. W., Rossen, R. D. and Hong, W. K. Immunologic determinants of head and neck cancer response to induction chemotherapy. J. Clin. Oncol. 7(7): 857-864, 1989.
13. Schantz, S.P., Savage, H. E., Racz, T., Taylor, D. L. and Sacks, P. G. Natural killer cells and metastases from pharyngeal carcinoma. Amer. J. Surg. 158: 361-366, 1989.
14. Bugis, S. P., Lotzova, E., Savage, H. E., Racz, T., Sacks, P. G. and Schantz, S. P. Inhibition of LAK generation by serum blocking factors in head and neck cancer patients. Cancer Immunol. Immunother. 31: 176-181, 1990.
15. Schantz, S. P., Savage, H. E., Brown, B. W., Young, G., Liu, F. J., Regger, G. and Newman, R. A. The significance of C1q binding macromolecules within the head and neck cancer patient. Cancer Res. 50: 4349-4354, 1990.
16. Racz, T., Sacks, P., Van, N. T., Taylor, D. L., Young, G., Bugis, S., Savage, H. E. and Schantz, S. P. The analysis of natural killer cell activity by flow cytometry. Arch. Otolaryngol. Head Neck Surg. 116: 440-446, 1990.
17. Schantz, S. P., Clayman, G. L., Liu, F. J., Lavedan, P., Pellegrino, C. and Savage, H. E. The in vitro biologic effect of interleukin-2 and interferon-alpha on natural immunity in head and neck cancer patients. Arch. Otolaryngol. 116:1302-1308, 1990
18. Lavedan, P., Savage, H. E., Lee, Y., Young, G. and Schantz, S. P. Circulating C1q binding macromolecules and its relationship to radiographic characteristics of laryngeal cancer. Arch. of Otolaryngol. Head and Neck Surgery. 117: 292-296, 1991.
19. Clayman, G. L., Savage, H. E., Ainsley, N., Liu, R. J. and Schantz, S. P. Serologic determinants of survival in patients with squamous cell carcinoma of the head and neck. Amer. J. Surg., 160(4):434-438, 1991.
20. Clayman, G. L., Liu, F. J., Taylor, D. L., Savage, H. E., Lavedan, P., Buchsbaum, R. M., Trujillo. J. M. and Schantz, S. P. Immunomodulation of the induction phase of lymphokine-activated killer activity by acute phase proteins. Otolaryngol. Head and Neck Surg. 105: 234-235, 1991.
21. Clayman, G. L., Savage, H. E. and Schantz, S. P. Surg. Forum., 1991.
22. Clayman, G. L., Young, G., Taylor, D. L., Savage, H. E., Lavedan, P., and Schantz, S. P. Detection of regulatory factors of lymphokine-activated killer cell activity in head and neck cancer patients treated with interleukin-2 and interferon alpha. Ann. Otol. Rhinol. Laryngol. 101:909-915, 1992.
23. Clayman, G. L., Liu, F. J., Savage, H. E., Taylor, D. L., Lavedan, P., Buchsbaum, R., Pellegrino, C., Trujillo, J. M., Young, G., Goepfert, H. and Schantz, S. P. Acute phase proteins in head and neck cancer patients treated with Interleukin-2/interferon alfa. Arch. Otolaryngol. Head Neck Surg. 118(1): 41-48, 1992.
24. Lydiatt, D. D., Savage, H. E., Clayman, G. L., Liu, F. J., Sample, D. and Schantz, S. Serologic determinants in patients with head and neck cancer: Validating a clinical prediction model. Laryngoscope 103: 13-16, 1993.
25. Schantz, S. P., Savage, H. E., Sacks, P. G., Silverberg, M., Lipkin, M., Yang K., Tang, G. C., Alfano, R. R. Tissue autofluorescence spectroscopy: an intermediate endpoint for chemopreventive agents. Proceedings of International Society for Optical Engineering 25:195-205, 1993.
26. Vlock, D. R., Schantz, S. P., Fisher, S. G., Savage, H. E., Carey, T. E., Wolf, G. T. Clinical correlates of circulating immune complexes and antibody reactivity in squamous cell carcinoma of the head and neck. J. Clin Oncol, 11(12):2427-2433, 1993.
27. Clayman, G. L., Taylor D. L., Liu, F. J., Lavedan, P., Savage, H. E., Burchsbaum. R. M., Trujillo, J. M. and Schantz, S.P. Serum and acute phase protein modulation of the effector phase of LAK cells. Laryngoscope 103:299-307, 1993.
28. Silberberg, M. B., Savage, H. E., Tang, G. C., Sacks, P. G., Alfano, R.R. and Schantz, S. P. Detecting retinoic acid induced biochemical alterations in squamous cell carcinoma using intrinsic fluorescence spectroscopy. Laryngoscope 104:278-283, 1994.
29. Savage, H. E., Kolli, V., Zhang, J., Alfano, R. R., Sacks, P. G. and Schantz, S. P. Tissue autofluorescence spectroscopy: in vivo alterations may reflect cellular proliferation. SPIE Proc 2135: 16-25, 1994.
30. Franceschi, D., Haldar, J., Alfano, R.R., Savage, H.E., Schantz, S.P. In-vivo fast fourier transform analysis of the autofluorescence of normal and neoplastic upper aerodigestive mucosa. Surgical Oncology, 8:488-492, 1994.
31. Glasgold, R., Glasgold, M., Savage, H., Pinto, J., Alfano, R., Schantz, S. P. Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis. Cancer Letters 85:223-232,1994.
32. Savage, H. E., Kolli, V., Ansley, J., Chandawarkar, R. Y., Alfano, R. R. and Schantz, S.P. Innate tissue fluorescence of the oral mucosa of controls and head and neck cancer patients. SPIE Proc 2387: 2-14, 1995.
33. Savage, H. E., Kolli, V., Saha, S., Zhang, J-C., Glasgold, M., Sacks, P.G., Alfano, R. R. and Schantz, S. P. Development of in vitro models to elucidate mechanisms of intrinsic cellular and tissue fluorescence. SPIE Proc 2387: 44-56, 1995.
34. Kolli, V. R., Shaha, A. R., Savage, H. E., Sacks, P. S., Casale, M. A. and Schantz. Native cellular fluorescence can identify changes in epithelial thickness in vivo in the upper aerodigestive tract. Amer. J. Surg. 170:495-498, 1995.
35. Kolli, V. R., Savage, H. E., Yao, T. J. and Schantz, S. P. Native cellular fluorescence of neoplastic upper areodigestive mucosa. Arch. Otolaryngol Head Neck Surg. 121:1287-1292, 1995.
36. Cordeiro, P. G., Kirschner, R. E., Hu, Q-Y., Chial, J. J. C., Savage, H., Alfano, R. R., Hoffman, L. A., and Hidalgo, H. Ultraviolet excitation fluorescence spectroscopy: A noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps. Plastic and Reconstructive Surg. 96:673-680, 1995.
37. Sacks, P. G., Savage, H. E, Levine. J., Kolli, V. R., Alfano, R. R. and Schantz, S. P. Native cellular fluorescence identifies terminal squamous differentiation of normal oral epithelial cells in culture: a potential chemoprevention biomarker. Cancer Letters 104:171-181, 1996.
38. Katz, A., Ganeson, S., Savage, H. E, Schantz, S. P. and Alfano, R. R. Optical biopsy fiber based on fluorescence instrumentation. SPIE 2679:118-123, 1996.
39. Davis, R. A., Savage, H. E., Alfano, R. R. and Schantz, S. P. Influence of keratin on native cellular fluorescence of human skin. SPIE 2679:216-226, 1996.
40. Demos, S. G., Savage, H., Heerdt, A. S., Schantz, S. and Alfano, R. R. Time resolved degree of polorization for human breast tissue. Optics Communications 124:439-442, 1996.
41. Demos, S. G., Savage, H. E., Heerdt, A. S., Schantz, S. and Alfano, R. R. Polarization imaging and characterization of human breast tissue. Adv. Optical Imaging and Photon Migration 2:113-115, 1996.
42. Liu. F., Shan. Y. X, Savage, H., Heerdt, A. S., Schantz, S., Celmer, E. and Alfano, R. R. Measurements of effective group index of refraction and scattering mean free path of normal and malignant human breast tissues using ultrafast optical techniques. Proc. Opt. Soc. Am. 2:376-378, 1996.
43. Zhang, J. C., Savage, H. E., Sacks, P. G., Delohery, T., Alfano, R. R., Katz, A. and Schantz, S. P. Innate cellular fluorescence reflects alterations in cellular proliferation. Lasers in Surg. Med. 20:319-331, 1997.
44. Schantz, S. P., Savage, H. E., Sacks, P. G. and Alfano, R. R. Native cellular fluorescence and its application to cancer prevention. Environ. Health Perspect.(Sup 105 pl. 4):941-944, 1997.
45. Guo, Y., Ho, P. P., Savage, H., Harris, D., Sacks, P., Schantz, S., Liu, F., Zhadin, N. and Alfano, R. Second-harmonic tomography of tissues. Optics Letters 22(17): 1323-1325, 1997.
46. Demos, S. G., Papadopoulos, A. J., Savage, H. E., Heerdt, A. S., Schantz, S. and Alfano, R. R. Polarization filter for biomedical tissue optical imaging. Photochem. Photobiol. 66(6): 821-825, 1997.
47. Katz, A., Savage, H. E., Zeng, F., Rome, J., Tang, C. C., Harris, D., Koutcher, J., Schantz, S. P., and Alfano, R. R. Ratio mapping system for tissue diagnosis. SPIE,3250:64-67, 1998.
48. Guo, Y., Liu, F., Zhadin, N., Ho, P. P., Savage, H., Harris, D., Sacks, P., Schantz, S. and Alfano, R. R. Second harmonic and two-photon fluorescence nonlinear optical histology of tissues. SPIE, 3250:210-212, 1998.
49. Yang, Y., Liu, C. H., Savage, H. E., Schantz, S. P. and Alfano, R. R. Optical fluorescence and Raman biopsy of squamous cell carcinoma from the head and neck. SPIE,3250:68-71, 1998.
50. Schantz, S. P., Kolli, V., Savage, H. E., Yu, G., Shah, J. P., Harris, D. E., Katz, A., Alfano, R.R. and Huvos, A. G. In vivo native cellular fluorescence and histological characteristics of head and neck cancer. Clin. Cancer Res. 4:1177-1182, 1998.
51. Carew, J. F., Federoff, H., Halterman, M., Kraus, D. H., Savage, H. E., Sacks, P. G., Schantz, S. P., Shah, J., and Fong, Y. Efficient gene transfer to human squamous cell carcinoma by the herpes simplex virus type I amplicon vector. Accepted Amer. J. Surg., 1998.